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目的比较分析不同级别心力衰竭(心衰)患者NT-proBNP、hs-CRP、cTnI左室射血分数(LVEF)的关系,探讨诊断左室心功能异常简单快速的方法。方法156例心衰患者按LVEF分为Ⅰ、Ⅱ、Ⅲ3组,20例健康体检者作为对照组,分别测定血清NT-proBNP、hs-CRP、cTnI及LVEF。结果心衰各组NT-proBNP、cTnI、hs-CRP高于对照组(P<0.01),LVEF低于对照组(P<0.01)。NT-proBNP、hs-CRP水平及LVEF在对照组、心衰Ⅰ组、Ⅱ组、Ⅲ组两两比较差异均有统计学意义(P均<0.05)。结论血清NT-proBNP、hs-CRP、cTnI水平与LVEF呈负相关(r=-0.67,P<0.01)。NT-proBNP、hs-CRP、cTnI联合测定对心衰的诊断、分级、预后评估具有重要的临床意义。
Objective To compare and analyze the relationship between NT-proBNP, hs-CRP and cTnI left ventricular ejection fraction (LVEF) in patients with different grades of heart failure (CHF) and to explore a simple and quick method for diagnosing left ventricular dysfunction. Methods 156 cases of heart failure patients were divided into Ⅰ, Ⅱ and Ⅲ groups according to LVEF and 20 healthy subjects as control group. Serum NT-proBNP, hs-CRP, cTnI and LVEF were measured respectively. Results The levels of NT-proBNP, cTnI and hs-CRP in each group were significantly higher than those in the control group (P <0.01). The LVEF was lower in the HF group than in the control group (P <0.01). The levels of NT-proBNP, hs-CRP and LVEF in the control group and heart failure group Ⅰ, Ⅱ and Ⅲ were significantly different (all P <0.05). Conclusions The serum levels of NT-proBNP, hs-CRP and cTnI are negatively correlated with LVEF (r = -0.67, P <0.01). NT-proBNP, hs-CRP, cTnI joint determination of the diagnosis of heart failure, grading, prognostic evaluation of important clinical significance.