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目的探讨尿前列腺素E_2(PGE_2)在溃疡性结肠炎(UC)中的表达及临床意义。方法检测46例UC动期患者(活动组)、30例UC缓解期患者(缓解组)及28例健康体检者(对照组)的血C反应蛋白(CRP)、粪钙卫蛋白(Cal)和尿PGE_2水平,分析尿PGE_2、粪Cal、血CRP水平与Mayo评分和Baron分级的相关性,并检测他们对疾病活动的诊断效能。结果活动组尿PGE_2、粪Cal、血CRP水平高于缓解组和对照组(P<0.05)。活动组尿PGE_2、粪Cal、血CRP水平与Mayo评分和Baron分级呈正相关(P<0.01或P<0.05)。尿PGE_2、粪Cal对疾病活动有较高的诊断效能(P<0.05)。结论尿PGE_2在UC活动期升高时,对UC疾病活动有较高的诊断价值。
Objective To investigate the expression of prostaglandin E_2 (PGE_2) in ulcerative colitis (UC) and its clinical significance. Methods Serum C-reactive protein (CRP), calreticulin (Cal), and total cholesterol in 28 patients with active UC (active group), 30 patients with UC remission (remission group) and 28 healthy controls (control group) Urinary PGE 2 levels, urinary PGE 2, fecal Cal, blood CRP levels and Mayo score and Baron grade correlation, and test their diagnostic efficacy of disease activity. Results Urine PGE 2, fecal Cal and blood CRP in active group were higher than those in remission group and control group (P <0.05). Urine PGE 2, faecal Cal and blood CRP level in active group were positively correlated with Mayo score and Baron grade (P <0.01 or P <0.05). Urine PGE 2, fecal Cal for the disease activity has a higher diagnostic efficacy (P <0.05). Conclusions Urinary PGE 2 has a higher diagnostic value for UC disease activity when the activity of UC increases.