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目的研究乳癌根治术后放化疗对乳腺癌中晚期患者机体免疫力的影响。方法对50例乳腺癌中晚期患者,采取乳癌根治术治疗,术后给予多西紫杉醇+顺铂化疗,并行三维适形放疗。分析50例患者术前术后CD4+、CD8+、CD4+/CD8+、NK和总有效率,12、24个月生存率。结果与术前比较,术后患者CD4+、CD8+、CD4+/CD8+、NK明显降低(P<0.05)。50例患者中完全缓解7例,部分缓解12例,稳定22例,进展9例,总有效率为82.00%;12个月生存率为80.00%,24个月生存率为30.00%。结论乳癌根治术后放化疗对乳腺癌中晚期患者机体免疫力的影响大,可降低患者免疫力水平,因此放化疗需注意加强对患者免疫指标和不良反应的监测,采取针对性治疗方案,改善患者预后。
Objective To study the effect of chemoradiotherapy after radiotherapy on the immunity of patients with advanced breast cancer. Methods Fifty patients with advanced breast cancer were treated with radical mastectomy. Docetaxel plus cisplatin was given postoperatively and three-dimensional conformal radiotherapy was performed. Fifty patients were analyzed preoperative and postoperative CD4 +, CD8 +, CD4 + / CD8 +, NK and total effective rate, 12,24 months survival rate. Results Compared with preoperative, the postoperative CD4 +, CD8 +, CD4 + / CD8 + and NK were significantly decreased (P <0.05). Among the 50 patients, complete remission was achieved in 7 cases, partial remission in 12 cases, stable in 22 cases and progression in 9 cases. The total effective rate was 82.00%. The 12-month survival rate was 80.00% and the 24-month survival rate was 30.00%. Conclusion Radiotherapy and chemotherapy after radical mastectomy have a great influence on the immunity of patients with advanced breast cancer, which can reduce the immunity of patients. Therefore, radiotherapy and chemotherapy should pay more attention to the monitoring of patients’ immune parameters and adverse reactions, and take targeted treatment to improve Patient’s prognosis.