目的探讨博来霉素(bleomycin,BLM)致大鼠肺纤维化机制。方法Ⅰ体内试验:雄性SD大鼠,体重220~250g,60只,随机分成对照组和BLM组(每组50只),用一次性气管内滴注BLM(5mg/kg,2mL/kg)的方法复制大鼠肺纤维化模型,对照组滴注生理盐水。在气管滴注BLM后第1、3、7、14和21天,取右肺进行 Objective To investigate the mechanism of pulmonary fibrosis induced by bleomycin (BLM) in rats. Methods Ⅰ In vivo experiments: Male Sprague-Dawley rats, weighing 220-250 g and 60, were randomly divided into control group and BLM group (50 in each group). The rats were treated with a single intratracheal instillation of BLM (5 mg / kg, 2 mL / kg) Methods Pulmonary fibrosis rat models were duplicated, and control group was given normal saline. On the 1st, 3rd, 7th, 14th and 21st days after intratracheal instillation of BLM, take the right lung