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选用氯化铝溶液制备拟痴呆小鼠动物模型，研究补肾中药对拟痴呆小鼠大脑皮层组织（Ｃｅｒ）中胆碱能Ｍ－受体结合容量（Ｒｔ）和胆碱酯酶（ＡｃｈＥ）活性的影响。结果表明，拟痴呆小鼠Ｃｅｒ中ＡｃｈＥ活性比正常青年小鼠明显提高（Ｐ＜０．０１），而Ｍ－受体Ｒｔ值显著降低（Ｐ＜０．００１）。补肾中药可明显降低拟痴呆小鼠Ｃｅｒ中ＡｃｈＥ，活性（Ｐ＜０．０５～０．０１），增加Ｍ－受体Ｒｔ值（Ｐ＜０．００１）。提示补肾中药能通过降低拟痴呆小鼠Ｃｅｒ中ＡｃｈＥ活性，增加Ｍ－受体Ｒｔ值，明显提高记忆能力。补肾中药有防治脑功能减退和防治早老性痴呆的作用。
An animal model of dementia mice was prepared using aluminum chloride solution to study the effects of Bushen herbs on cholinergic M-receptor binding capacity (Rt) and cholinesterase (AchE) activity in cerebral cortex (Cer) of dementia mice. influences. The results showed that the activity of AchE in dementia mice was significantly higher than that in normal young mice (P<0.01), while the M-receptor Rt was significantly lower (P<0.001). Kidney-reinforcing Chinese herbs can significantly reduce the AchE activity in the dementia mouse Cer (P<0.05-0.01) and increase the M-receptor Rt (P<0.001). Tips Bushen Chinese medicine can significantly increase the memory capacity by decreasing the AchE activity in the dementia mouse Cer and increasing the M-receptor Rt value. Kidney-tonifying Chinese herbs have the effect of preventing and treating brain dysfunction and preventing and treating Alzheimer’s disease.