目的建立用H PLC法测定呋麻滴鼻剂含量的方法。方法用十八烷基键合硅胶为固定相shim pack-ODS柱,以0.05M磷酸缓冲液:乙腈(85:15)为流动相,调节PH值为3.0,检测波长为254nm。结果盐酸麻黄碱在0.1～0.8m g/m l浓度范围内线性关系良好(r=0.999992,n=7);呋喃西林在2.0～16.6ug/m l浓度范围内线性关系良好(r=0.999990,n=7);而两者的回收率分别为101.3%(RSD=0.2%n=5),101.0%(RSD=0.3%N=5)。结论本方法简单,重现性好,是本品质量分析和控制很好的方法。 Objective To establish a method for determining the content of furosemide nasal drops by H PLC method. Methods The octadecyl-bonded silica gel was used as the stationary phase shim pack-ODS column. The mobile phase consisted of 0.05 M phosphate buffer and acetonitrile (85:15). The pH was 3.0 and the detection wavelength was 254 nm. Results Ephedrine hydrochloride showed a good linearity (r = 0.999992, n = 7) in the concentration range of 0.1-0.8 mg / ml, and a good linear relationship was found in the range of 2.0-16.6 μg / ml of nitrofurazone (r = 0.999990, n = 7) ; While the recoveries of the two were 101.3% (RSD = 0.2% n = 5) and 101.0% (RSD = 0.3% N = 5) respectively. Conclusion This method is simple, reproducible, is a good method of quality analysis and control of this product.