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目的 探讨治疗头颈与消化道癌实用有效的化疗方案。方法 采用大剂量醛氢叶酸(HD CF) +5 氟尿嘧啶 (5 Fu)为主的联合化疗方案 ,持续滴注 48h ,治疗头颈与消化道癌 5 6例 ,每例患者平均 3.8个周期 (2～ 6周期 )。结果 全组患者有效率 (CR +PR)为 35 .7% ,临床受益率达 80 .4%。不良反应为外周静脉炎、骨髓抑制、口腔溃疡和恶心呕吐等 ,但多为Ⅰ～Ⅱ度。结论 大剂量醛氢叶酸 +5 氟尿嘧啶为主的联合化疗方案 ,持续滴注 48h ,治疗头颈与消化道癌疗效较满意 ,经济实用 ,值得进一步研究。
Objective To investigate the practical and effective chemotherapy for the treatment of head and neck and gastrointestinal cancer. Methods High-dose combination of HDF and 5 Fu combined with chemotherapy was used to treat 56 cases of head and neck and digestive tract cancers for 48 hours. Each patient had an average of 3.8 cycles (2 ~ 6 cycles). Results The overall effective rate (CR + PR) was 35.7%, and the clinical benefit rate was 80.4%. Adverse reactions were peripheral phlebitis, myelosuppression, oral ulcers and nausea and vomiting, but mostly Ⅰ ~ Ⅱ degrees. Conclusions High-dose combination of dihydrofolate and 5-fluorouracil is the most effective chemotherapy for head and neck and digestive tract cancer. It is economical and practical and worth further study.