最近发现一种称为SLAT(类似SWAP70的细胞接头蛋白)的蛋白。Becart等报道,T细胞的发育、激活和效应功能都需要SLAT,且它是通过控制钙信号转导途径来实现的。SLAT(也称IBP)是一个鸟嘌呤核苷酸交换因子,随着T细胞受体的配体化而被激活。Becart等研究发现,SLAT缺陷小鼠的胸腺细胞发 Recently a protein called SLAT (a SWAP70-like cell adapter protein) was discovered. Becart et al. Reported that SLAT is required for the development, activation and effector function of T cells, and it is through the control of calcium signaling pathways. SLAT (also known as IBP) is a guanine nucleotide exchange factor that is activated as ligands for T cell receptors. Becart and other studies found that SLAT-deficient mice thymus hair