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目的评价血痛定巴布剂的抗炎镇痛作用。方法采用炎症、疼痛动物模型,观察血痛定巴布剂的药效作用。结果血痛定巴布剂可显著降低小鼠腹腔毛细血管通透性,可显著降低二甲苯所致耳廓肿胀和小鼠肉芽肿,可显著抑制角叉菜胶所致足趾肿胀;可显著减少醋酸致小鼠扭体次数,对小鼠热刺激所致痛阈值的变化不明显。结论血痛定巴布剂具有明显的抗炎作用,无镇痛作用。
Objective To evaluate the anti-inflammatory and analgesic effect of Xuebong Dingbubuji. Methods The model of inflammation and pain was used to observe the pharmacodynamic effects of Xuebeng Dingbubu. Results Hematongding poultice can significantly reduce the peritoneal capillary permeability of mice, can significantly reduce xylene-induced ear swelling and mouse granuloma, can significantly inhibit the carrageenan caused by toe swelling; can be significantly Reduce the number of writhing caused by acetic acid in mice, thermal stimulation induced changes in the threshold of pain is not obvious. Conclusion Hematsuding poultice has obvious anti-inflammatory effect, no analgesic effect.