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对１９８７年～１９８９年３０例有干骺端病变的大骨节病人（下简称ＫＢＤ）进行了病例对照研究。结果：病例组发硒含量均值为４４．５６±３４．２３ｎｇ／ｇ，对照组为８０．３３±３６．４２ｎｇ／ｇ，ｔ＝３．９７，Ｐ＜０．００１；尿硒２４ｈ排泄量病例组为２．１８２４±０．９４２１μｇ，对照组为２．６６９９±０．９７７５μｇ，ｔ＝０．７７６，Ｐ＞０．０５。发硒和尿硒结果不一致，难以判断硒与ＫＢＤ有无联系。又进行１：１配对病例对照研究，结果发硒含量与ＫＢＤ的ＯＲ＝２．０，ｘ２＝０．４４４；尿硒排泄量与ＫＢＤ的ＯＲ＝１．６６７，ｘ２＝０．５６，二者Ｐ值均大于０．０５，表明发硒和尿硒一致的与ＫＢＤ联系不密切。经验证，病例组和对照组发硒均值的差异可能是由偶然机会引起。
A case-control study was performed on 30 patients with KBD who had metaphyseal lesions from 1987 to 1989. Results: The average selenium content in case group was 44.56 ± 34.23ng / g, the control group was 80.33 ± 36.42ng / g, t = 3.97, P <0.001; Group was 2.1824 ± 0.9421μg, the control group was 2.6699 ± 0.9775μg, t = 0.776, P> 0.05. Hair selenium and urinary selenium results are inconsistent, it is difficult to determine whether the relationship between selenium and KBD. A 1: 1 pairwise case-control study was also performed. Results The selenium content and KBD OR = 2.0 and x2 = 0.444. The excretion of urinary selenium and KBD were 1.667 and x2 = 0.56, respectively P values were greater than 0.05, indicating that hair selenium and urine selenium consistent with the KBD not close. It has been verified that differences in mean selenium values between cases and controls may be caused by chance.