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白细胞介素与自身免疫的最初实验研究是在动物中进行的,某些小鼠可发生酷似人类SLE的自身免疫病.NZB与NZW的杂交鼠-F_1及BXSB发生自身免疫病的严重性随性别而异;但带Lpr基因的MRL系小鼠中,雌雄均可很早发生极严重的自身免疫病.上述这些小鼠都能产生大量抗体,形成循环免疫复合物;并有胸腺萎缩、神经节增生;细胞毒T细胞攻击自身组织的反应增高;但非特异性Ts细胞正常,且能被ConA激活.上述结果表明,这些小鼠B细胞内源性多克隆活化物(MRL Lpr小鼠的活化物可能是辅
The initial experimental study of interleukin and autoimmunity was performed in animals and some mice developed an autoimmune disease that resembles human SLE.The severity of autoimmune disease in mice with ZN and NZW crossings-F_1 and BXSB varies according to gender However, in MRL mice with Lpr gene, very severe autoimmune diseases could occur very early in both male and female.All these mice could produce a large number of antibodies to form circulating immune complexes, with thymus atrophy and ganglion hyperplasia ; Cytotoxic T cells attack their own tissues increased response; however, nonspecific Ts cells are normal and can be activated by Con A. These results suggest that the endogenous polyclonal activators of these mouse B cells (MRL Lpr mouse activators may Is auxiliary