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目的观察促红细胞生成素在短肠综合征治疗中的作用。方法短肠综合征患儿14例依据住院时间分为2组,2006年1月—2009年6月住院7例短肠综合征患儿为对照组,采用传统肠外营养、肠内营养治疗;2009年7月—2012年2月住院7例短肠综合征患儿为观察组,在对照组治疗基础上应用促红细胞生成素。比较2组肠外营养时间、住院时间、出生后100d及6个月体质量增加、出院后1a内住院次数。结果观察组肠外营养时间、住院时间较对照组短(P<0.05),出生后100d及6个月体质量增加高于对照组(P<0.05),出院后1a内住院次数低于对照组(P<0.05)。结论短肠综合征患儿应用促红细胞生成素可缩短肠外营养和住院时间,减少1a内住院次数,增加体质量。
Objective To observe the role of erythropoietin in the treatment of short bowel syndrome. Methods Fourteen patients with short bowel syndrome were divided into two groups according to length of hospital stay. Seven children with short bowel syndrome admitted to hospital from January 2006 to June 2009 were selected as control group. The patients were treated with traditional parenteral nutrition and enteral nutrition. July 2009 - February 2012 hospitalized 7 cases of short bowel syndrome in children as the observation group, the control group based on the application of erythropoietin. The parenteral nutrition time, hospitalization time, 100d and 6months after birth were compared, and the number of inpatients within 1 day after discharge was compared. Results The parenteral nutrition time and hospitalization time in the observation group were shorter than those in the control group (P <0.05). The body weight at 100 days and 6 months after birth was significantly higher than that in the control group (P <0.05) (P <0.05). Conclusion The application of erythropoietin in children with short bowel syndrome can shorten the time of parenteral nutrition and hospitalization, reduce the frequency of hospitalization in 1a and increase the body weight.