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目的探讨蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的发病机理和防治方法。方法采用放免法动态观察了犬SAH后血浆、CSF中神经肽Y(NPY)、心钠素(ANP)含量动态变化及巴曲酶的保护作用。结果单纯注血组及巴曲酶治疗组血浆、CSF中NPY、ANP含量较注血前及同期正常对照组明显增高(P<0.01);单纯注血组在注血后30min血浆、CSF中NPY含量开始升高,CSF中ANP含量亦在注血后30min升高,血浆ANP含量则在第2d开始升高,至第7d最高。蛛网膜下腔给药组和静脉注入巴曲酶0.4BUkg-1d-1组血浆、CSF中NPY、ANP含量均明显低于同期单纯注血组(P<0.01)。结论血浆、CSF中NPY、ANP的异常增高是SAH后CVS的原因之一,巴曲酶可以防止NPY和ANP的异常增高。
Objective To investigate the pathogenesis and prevention of cerebrovascular spasm (CVS) after subarachnoid hemorrhage (SAH). Methods The dynamic changes of neuropeptide Y (NPY), atrial natriuretic peptide (ANP) and the protective effect of batroxobin in plasma and CSF of dogs after SAH were observed dynamically by radioimmunoassay. Results The levels of NPY and ANP in the plasma and CSF of the simple injection group and the batroxobin group were significantly higher than those of the normal control group and the normal control group (P <0.01) The content of ANP in CSF began to increase. The content of ANP in CSF also increased 30min after injection, and the content of plasma ANP increased from the 2nd day to the 7th day. The contents of NPY and ANP in the plasma and CSF of the subarachnoid administration group and the intravenous injection of batroxobin 0.4BUkg-1d-1 group were significantly lower than those of the pure injection group (P <0.01). Conclusion The abnormal increase of NPY and ANP in plasma and CSF is one of the causes of CVS after SAH. Batroxobin can prevent the abnormal increase of NPY and ANP.