论文部分内容阅读
目的:研究71例正常胃粘膜,胃粘膜炎症伴中、重度不典型增生、早期胃癌和进展期胃癌标本,了解肿瘤抑癌基因与胃癌的关系.方法:用免疫组化方法观察p21、p53和p16蛋白表达.结果:p21与p53的上调性阳性表达与不典型增生的程度有关,而P16呈下调性表达改变.结论:p21、p53及p16的表达异常与胃癌发生有关.检测这些指标可作为胃癌癌前病变的显著性标志.
Objective: To study the relationship between tumor suppressor gene and gastric cancer in 71 patients with normal gastric mucosa, gastric mucosal inflammation, moderate and severe atypical hyperplasia, early gastric cancer and advanced gastric cancer.Methods: The expressions of p21, p53 and p16 protein expression.Results: The positive expression of p21 and p53 was related to the degree of atypical hyperplasia, while the expression of P16 was down-regulated.Conclusion: The abnormal expression of p21, p53 and p16 is related to the occurrence of gastric cancer.The detection of these indexes can be used as Significant sign of gastric precancerous lesions.