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目的:观察Endoglin(又称CD105)在皮肤鳞状细胞癌(皮肤鳞癌)中的表达情况及特点,探讨其在皮肤鳞癌中的可能作用。方法:根据Broders分级(按未分化癌细胞所占的百分比)将皮肤鳞癌分为高分化鳞癌组(Ⅰ级,14例)、中分化鳞癌组(Ⅱ级,12例)和低分化鳞癌组(Ⅲ级~Ⅳ级,26例);根据是否伴有淋巴结转移分为伴有淋巴结转移组11例,无转移组41例。采用免疫组织化学EliVision法对皮肤鳞癌组及对照组(10例)正常皮肤染色。观察Endoglin在正常皮肤对照组及皮肤鳞癌组中的表达,分析Endoglin-微血管密度(microvessel density,MVD)在不同组织中、不同病理分组及临床分组中的表达。结果:皮肤鳞癌组Endoglin-MVD(30.56±6.41)显著高于正常对照组(3.00±1.63)(P<0.01);中-低分化组(31.95±5.74)显著高于高分化组(26.79±6.83)(P<0.01);淋巴结转移组(34.73±4.50)显著高于无转移组(29.44±6.43)(P<0.05)。结论:Endoglin-MVD的增加可能与皮肤鳞癌的发生、分化程度的降低及淋巴结转移的出现有关。
Objective: To observe the expression and characteristics of Endoglin (aka CD105) in cutaneous squamous cell carcinoma (SCC) and to explore its possible role in SCC. Methods: The squamous cell carcinoma was divided into well-differentiated squamous cell carcinoma (Ⅰ grade, 14 cases), moderately differentiated squamous cell carcinoma (Ⅱ grade, 12 cases) and poorly differentiated squamous cell carcinoma Squamous cell carcinoma (Grade Ⅲ ~ Ⅳ, 26 cases). According to whether lymph node metastasis or not, there were 11 cases with lymph node metastasis and 41 cases without metastasis. Immunohistochemistry EliVision method for squamous cell carcinoma and control group (10 cases) normal skin staining. The expression of Endoglin in normal skin and squamous cell carcinoma was observed and the expression of Endoglin-microvessel density (MVD) in different tissues, different pathological groups and clinical groups was analyzed. Results: Endoglin-MVD (30.56 ± 6.41) in squamous cell carcinoma was significantly higher than that in normal control (3.00 ± 1.63) (P <0.01), moderately-poorly differentiated (31.95 ± 5.74) 6.83) (P <0.01). The lymph node metastasis group (34.73 ± 4.50) was significantly higher than that of the non-metastasis group (29.44 ± 6.43) (P <0.05). Conclusion: The increase of Endoglin-MVD may be related to the occurrence and differentiation of squamous cell carcinoma and the occurrence of lymph node metastasis.