论文部分内容阅读
本文对目前临床应用的40余种抗菌素有关药理学方面的作用,分两部分加以叙述。一、抗菌素对细菌和真菌的作用原理: 1.作用在细菌细胞壁的药物:青霉素族、头孢菌素族、环丝氨酸、万古霉素、瑞斯托霉素和杆菌肽。 2.作用在细菌细胞膜,产生去垢剂样作用的药物:多粘菌素B、多粘菌素E以及多烯类抗真菌药物如制霉菌素和二性霉素B。 3.通过对核糖体的作用改变复制、信息传递和蛋白合成的分子机理的药物:氯霉素、四环素族、卡那霉素、新霉素、新生霉素、庆大霉素、巴龙霉素、链霉素和大环内脂类红霉素、林可霉素。 4.改变核酸代谢的药物:灰黄霉素和
This article on the current clinical application of more than 40 kinds of antibiotics pharmacological aspects, in two parts to be described. First, the role of antibiotics on bacteria and fungi Principle: 1 role in the bacterial cell wall drugs: penicillin family, cephalosporins, cycloserine, vancomycin, ristocetin and bacitracin. 2. acting on the bacterial cell membrane, produce detergent-like drugs: polymyxin B, polymyxin E and polyene antifungal drugs such as nystatin and amphotericin B. 3. Drugs that alter the molecular mechanisms of replication, message transmission and protein synthesis by acting on ribosomes: chloramphenicol, tetracyclines, kanamycin, neomycin, novobiocin, gentamycin, Streptomycin and Macrolides Erythromycin, Lincomycin. 4. Change the nucleic acid metabolism drugs: griseofulvin and