Mutations in the p16 gene in DMBA-induced pancreatic intraepithelial neoplasia and pancreatic cancer

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<正>BACKGROUND:7,12-dimethylbenzanthracene(DMBA)-induced pancreatic intraepithelial neoplasia(PanIN)and pancreatic cancer in rats provide a classic model for uncovering the molecular mechanisms underlying pancreatic cancer.However,this model has not
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