目前的抗生素均作用于4种细胞过程之一,而细菌已经产生了多种抗药途径,因此寻找新作用机制的药物迫在眉睫。Blount等研究发现,细菌的核糖开关(作为代谢传感器调节相关基因表达的特定RNA结构)代表了一类新的抗菌靶标。核糖开关存在于细菌mRNA的5′非翻译区,能够与特定代谢产物结 Current antibiotics all act on one of the four cellular processes, and bacteria already have multiple drug resistance pathways, so it is imperative to look for new mechanisms of action. Blount et al. Found that the bacterial ribosomal switch (a specific RNA structure that regulates the expression of related genes as a metabolic sensor) represents a new class of antimicrobial targets. Riboswitches reside in the 5 ’untranslated region of bacterial mRNA and can bind to specific metabolites