肺静脉闭塞病(pulmnonary veno-occlusive disease,PVOD)是肺高血压的一种罕见亚型,以主要累及肺静脉为特征。PVOD需要通过组织学来确诊,但在这些高危患者中进行肺活检存在高风险。目前基于临床和影像学评估等无创方法有助于诊断PVOD。PVOD的病理生理机制尚不清楚。已证实多种药物能引起PVOD,特别是化疗药物,如博来霉素、卡 Pulmonary non-venous occlusive disease (PVOD) is a rare subtype of pulmonary hypertension characterized by the predominant involvement of the pulmonary veins. PVOD needs to be diagnosed histologically, but there is a high risk of lung biopsy in these high-risk patients. Noninvasive methods such as clinical and imaging assessments are currently available to help diagnose PVOD. The pathophysiology of PVOD is not clear. A variety of drugs have been shown to cause PVOD, especially chemotherapy drugs such as bleomycin, card