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1933年Ｒｉｖｅｒｓ等采用多次肌肉注射兔脑提取物的方法 ,首次成功建立了和人类多发性硬化 (ｍｕｌ ｔｉｐｌｅｓｃｌｅｒｏｓｉｓ ,ＭＳ)临床特征和病理改变相似的动物模型 ,即实验性过敏性脑脊髓炎 (ｅｘｐｅｒｉｍｅｎｔａｌａｌｌｅｒ ｇｉｃｅｎｃｅｐｈａｌｏｍｙｅｌｉ
In 1933, Rivers and many other intramuscular injection of rabbit brain extract method for the first time successfully established and human clinical symptoms and pathological changes of multiple sclerosis (mul tiplesclerosis, MS) animal model, namely experimental allergic encephalomyelitis experimentalaller gicencephalomyeli