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目的:研究大黄苏打片对中晚期原发性肝癌的佐治及对并发症的防治作用。方法:对收治我院的76例中晚期原发性肝癌患者,36例列入大黄苏打片治疗组,对照组36例,两组病人病情及其他治疗方法无差异。统计观察两组病人主要症状、肝功能指标、甲胎蛋白变化及主要并发症防治效果。结果:治疗组乏力、纳差、腹胀等症状改善显著优于对照组(P<0.05),丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)、甲胎蛋白(AFP)改善显著优于对照组(P<0.05或P<0.01),腹(胸)水、上消化道出血、肝肾综合征、肝性脑病、感染、电解质与酸碱失衡、心衰、呼衰等主要并发症发生率显著低于对照组(P<0.05或P<0.01),并发症治疗有效病例疗程显著短于对照组(P<0.05)。结论:大黄苏打片佐治中晚期原发性肝癌,对于改善患者病情、防治并发症具有重要意义。
Objective: To study the effect of rhubarb soda tablet on adjuvant treatment of advanced primary hepatocellular carcinoma and its prevention and treatment. Methods: Of the 76 patients with advanced primary liver cancer treated in our hospital, 36 were included in the treatment group of rhubarb and soda, and 36 in the control group. There was no difference between the two groups in disease and other treatment methods. The main symptoms, liver function indexes, alpha-fetoprotein changes and the prevention and treatment of major complications in the two groups were observed. Results: The improvement of symptom such as fatigue, anorexia and bloating in treatment group was significantly better than that in control group (P <0.05), ALT, TBiL and AFP were significantly improved (P <0.05 or P <0.01), abdominal (chest) water, upper gastrointestinal bleeding, hepatorenal syndrome, hepatic encephalopathy, infection, electrolyte and acid-base imbalance, heart failure, respiratory failure and other major complications The incidence of disease was significantly lower than that of the control group (P <0.05 or P <0.01). The effective course of treatment for complications was significantly shorter than that of the control group (P <0.05). Conclusion: Rhubarb soda tablet in the treatment of advanced primary liver cancer, for improving the patient’s condition, prevention and treatment of complications is of great significance.