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目的研究慢性炎症因子白细胞介素18(IL~(-1)8)在多囊卵巢综合征(PCOS)发病过程中的作用,并探讨补肾活血方的干预作用。方法应用补肾活血方作用于以脱氢表雄酮(DHEA)诱导的PCOS大鼠模型,观察IL~(-1)8浓度变化。结果PCOS大鼠模型血清IL~(-1)8浓度升高,但干预前后差异无统计学意义(P>0.05)。补肾活血方干预后血清IL~(-1)8浓度降低,与干预前比较差异有统计学意义(P<0.05);给药后对照组、达英组、中药组与模型组相比排卵率增高,差异有统计学意义(P<0.05)。结论 PCOS的发生可能与慢性炎症有关,补肾活血方能改善卵巢功能,促进卵泡发育,对多囊卵巢综合征的发病有一定的干预作用。
Objective To investigate the role of interleukin 18 (IL-8), a chronic inflammatory cytokine, in the pathogenesis of polycystic ovary syndrome (PCOS) and to explore the effect of Bushen Huoxue prescription. Methods Bushen Huoxue Fang was administered to rats with PCOS induced by dehydroepiandrosterone (DHEA), and the concentration of IL - (-1) 8 was observed. Results The concentration of IL - (1) 8 in PCOS rat model increased but there was no significant difference before and after intervention (P> 0.05). After intervention of Bushen Huoxue Recipe, the concentration of IL-8 in serum decreased significantly compared with that before intervention (P <0.05). After administration, the ovulation rate of control group, Increased, the difference was statistically significant (P <0.05). Conclusions The occurrence of PCOS may be related to chronic inflammation. Bushen Huoxue Decoction can improve ovarian function and promote follicular development, which may interfere with the pathogenesis of PCOS.