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In order to examine the severity of reflux esophagitis and the methods of manometry and 24 hour ambulatory pHmonitoring, 100 gastroesophageal reflux disease (GERD) patients were examined. The results were compared with acontrol group which consisted of 30 healthy individuals. Endoscopy was performed, and esophageal mucosa biopsieswere taken in all patients. Esophageal manometry was recorded using a four tune water perfused system. The severi-ty of esophagitis, determined by both endoscopy and histology, was related to the amplitude of esophageal perista1ticwaves, in partictilar the cardioesophageal sphincter (CES) dysfunction (P < 0. 01), 24 hour reflux total score. Wehave concluded that the severity of reflux esophagitis is related to the duration of reflux, which in turn is associatedwith the impairment of esophageal body motility and CES dysfunction.
In order to examine the severity of reflux esophagitis and the methods of manometry and 24 hour ambulatory pHmonitoring, 100 gastroesophageal reflux disease (GERD) patients were examined. The results were compared with acontrol group consisted of 30 healthy individuals. Endoscopy was performed, and The severi-ty of esophagitis, determined by both endoscopy and histology, was related to the amplitude of esophageal perista1ticwaves, in partictilar the cardioesophageal sphincter (CES Wehave concluded that the severity of reflux esophagitis is related to the duration of reflux, which in turn is associated with the impairment of esophageal body motility and CES dysfunction.