论文部分内容阅读
目的根据现有临床研究评价对心肺复苏过程中进行溶栓治疗的有效性和安全性。方法从1966-01-01-2004-08-01MEDLINE光盘数据库,检索以心跳骤停后进行心肺复苏术的患者为研究对象,比较溶栓与非溶栓治疗效果的临床研究文献,并对文献结果进行Meta分析。结果共9篇临床研究文献入选。心肺复苏过程中进行溶栓治疗可以显著提高自主循环恢复率、24小时存活率、出院率并改善远期神经功能(P<0·01)。相比非溶栓治疗,溶栓治疗显著增加了严重性出血的发生率(P<0·01)。结论与非溶栓治疗比较,溶栓治疗增加了的严重性出血的发生率。但从整体而言,心肺复苏术过程中进行溶栓治疗可以显著提高患者的出院率并改善远期神经功能。
Objective To evaluate the effectiveness and safety of thrombolytic therapy during cardiopulmonary resuscitation based on available clinical studies. Methods From 1966-01-01-2004-08-01 MDEDLINE CD-ROM, we searched the clinical research literature comparing the efficacy of thrombolytic and non-thrombolytic therapy in patients with cardiopulmonary resuscitation after cardiac arrest. Meta-analysis. Results A total of 9 clinical studies were selected. Cardiopulmonary resuscitation thrombolytic therapy can significantly improve spontaneous circulation recovery rate, 24-hour survival rate, discharge rate and improve long-term neurological function (P <0.01). Thrombolytic therapy significantly increased the incidence of severe bleeding compared with non-thrombolytic therapy (P <0.01). Conclusions Thrombolytic therapy increases the incidence of severe bleeding compared with non-thrombolytic therapy. Overall, however, thrombolysis during cardiopulmonary resuscitation can significantly improve patient discharge and improve long-term neurological function.