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Fenoterol(酚间羟异丙肾上腺素)是一种新的长效枝气管扩张剂。作者选择19例枝气管哮喘患者。如已使用类固醇或色甘酸钠治疗,要求剂量稳定。试验前8和12小时内,禁用短效和长效的交感胺类药物。在使用试验药物前,用肺活量计测定第一秒钟用力呼气量(FEV_1)假如使用异丙肾上腺素后,FEV_1值超过使用前80%,改日再作试验;如<80%,即双盲给予吸入下列5种试验药物之一:0.1,0.2或0.4mg的酚间羟异丙肾上腺素,或0.15mg的异丙肾上腺素,或安慰剂。用药后1、15、30分钟和1、2、3、4、5、6、8小时各测FEV_1。同时测血压、脉搏、心率和询问有何不适感。
Fenoterol (Phenyletophenolate) is a new long-acting bronchodilator. The authors selected 19 patients with bronchial asthma. If treated with steroids or cromolyn, dose stability is required. Short and long-acting sympatholytics are disabled for the first 8 and 12 hours before the test. Before the use of test drugs, spirometer measured first second forced expiratory volume (FEV_1) If the use of isoproterenol, FEV_1 value of more than 80% before use, and then make another test; such as <80%, that is, double Blind administration inhaled one of the following five test drugs: 0.1, 0.2 or 0.4 mg of phenylethasone, or 0.15 mg of isoproterenol, or placebo. 1, 15, 30 minutes after treatment and 1, 2, 3, 4, 5, 6, 8 hours after each treatment FEV_1. Also measure blood pressure, pulse, heart rate and ask what discomfort.