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分娩对刺激表面活化剂的产生与释放有无作用,仍缺乏证据。Rooney等(1977)报导,家兔分娩可增加肺灌洗液内磷脂的含量及肺组织磷酸胆硷转移酶的活性。Whittle等(1977)与Cabero等(1976)报导,人类分娩时出现卵磷脂与鞘磷脂比值(L/S)上升现象,故分娩有可能刺激表面活性剂的作用。以往报导指出,L/S比值的变化并不一致,其上升常伴随较短的产程,因而推测皮质醇(Cortisol)可能在子宫收缩效率及上升的L/S比值之间起连接作用。作者拟对这一假说进行深入研究。 24例孕妇(38～40周)接受引产,指征为孕足月体重下降、过期妊娠或子痫前期。人工破膜后即静滴催产素,每例均行超声波胎头测量,产后检查婴儿以确定胎龄。无1例发生呼吸窘迫综合症。破膜时,插入宫腔一塑料导管,每小时吸取羊
There is still no evidence of the role of labor in stimulating the production and release of surfactant. Rooney et al. (1977) reported that labor in rabbits increased phospholipid levels in lung lavage fluid and lung phosphorylase activity. Whittle et al. (1977) and Cabero et al. (1976) reported that rising lecithin to sphingomyelin ratio (L / S) occurred during human delivery, so delivery may stimulate the action of surfactants. Previous reports indicated that the changes in L / S ratio were inconsistent and their rise was often accompanied by a short course of labor, suggesting that Cortisol may have a connection between uterine contractility and increased L / S ratio. The author intends to conduct an in-depth study of this hypothesis. Twenty-four pregnant women (38-40 weeks) received induction of labor, indicating full-term pregnancy weight loss, expired pregnancy or preeclampsia. Artificial rupture of membranes that intravenous oxytocin, ultrasound ultrasound fetal head were measured in each case, postpartum check the baby to determine the gestational age. No case of respiratory distress syndrome. Rupture of the membrane, insert a plastic catheter uterine cavity, absorb the sheep every hour