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我们对25例非酒精性肝硬化患者用口服锌耐量试验检查锌吸收情况,并与健康对照组比较.口服锌22.5mg,在非酒精性肝硬化患者,血浆锌增高显著低于健康对照组,具有统计学意义,在第一和第二小时,P<0.01;在第四小时,P<0.05.锌吸收不良可能由于异常小肠粘膜所致。在所有患者小肠粘膜活检中,都显示绒毛部分缩短及显著肿胀,固有膜内间质高度水肿及炎性细胞浸润.但是,小肠的这些病理改变是由于锌缺乏还是由于门脉高压所致还不清楚.然而,锌吸收不良引起非酒精性肝硬化患者锌缺乏似乎起了一定作用,并且在部分
Twenty-five patients with non-alcoholic cirrhosis were examined for zinc absorption by oral zinc tolerance test and compared with healthy controls.Oral zinc was 22.5 mg, and in patients with non-alcoholic cirrhosis, plasma zinc increased significantly lower than that in healthy controls, Statistically significant, P <0.01 at the first and second hours, P <0.05 at the fourth hour, and poor malabsorption of Zinc may be due to abnormal small intestinal mucosa. Small intestinal mucosal biopsies showed shortening and significant villi in all patients with a high degree of edema and inflammatory cell infiltration in the intrinsic membrane but these pathological changes in the small intestine were due to zinc deficiency or to portal hypertension Clearly, however, zinc deficiency in patients with non-alcoholic cirrhosis seems to play a role in zinc malabsorption and, in part