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应用小剂量肝素钙治疗反复发作的缓解期儿童哮喘83例,sc30~50IU/kg,每天1次,10次为1疗程,分别1~3个疗程不等。疗效以治疗前后自身对照,随访18mo~3a。结果:临控22.89%、显效45.78%、好转28.90%、无效2.40%,总有效率97.60%。治疗后CD3、CD4、CD4/CD8明显上升,IgE显著下降。说明小剂量肝素钙能促使CD3、CD4升高,调节CD4/CD8,从而降低IgE水平,消除气道高反应性。证实小剂量肝素钙皮下注射可作为儿童哮喘的综合治疗方法之一。
Application of low-dose heparin calcium in children with recurrent remission 83 cases of childhood asthma, sc30 ~ 50IU / kg, 1 times a day, 10 times for a course of treatment, respectively, ranging from 1 to 3 courses. Efficacy before and after treatment to control their own, followed up 18mo ~ 3a. Results: Pro-control was 22.89%, effective 45.78%, improvement 28.90%, ineffective 2.40%, the total effective rate was 97.60%. After treatment CD3, CD4, CD4 / CD8 increased significantly, IgE decreased significantly. The results showed that low-dose heparin calcium can promote CD3, CD4, regulate CD4 / CD8, thereby reducing the level of IgE, to eliminate airway hyperresponsiveness. Confirmed that low-dose heparin calcium subcutaneous injection can be used as a comprehensive treatment of asthma in children.