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目的比较吡柔比星(THP)两种膀胱内灌注方法预防浅表性膀胱癌术后复发的有效性及安全性。方法将80例经尿道膀胱癌电切术后浅表性膀胱癌患者随机分为2组,均于术后1周开始灌注,每次THP灌注剂量40 mg,每周灌注1次,连续8周,再改为每月灌注1次,至术后1年。灌注前实验组THP用蒸馏水80 mL稀释,对照组THP用蒸馏水40 mL稀释。结果全部病例均获随访,时间为2年,2组复发率比较差异无统计学意义(P>0.05),不良反应发生率实验组显著低于对照组(P<0.05)。结论 THP 40 mg+蒸馏水80 mL膀胱灌注方法可以明显降低肿瘤患者术后吡柔比星膀胱灌注的不良反应,值得推荐。
Objective To compare the efficacy and safety of two intravesical instillation methods of pirarubicin (THP) in preventing postoperative recurrence of superficial bladder cancer. Methods Totally 80 patients with superficial bladder cancer after transurethral resection of bladder cancer were randomly divided into 2 groups. All the patients were started perfusion at 1 week after operation. Each THP was given 40 mg once a week for 8 weeks , Then changed to perfusion once a month, to 1 year after surgery. Before perfusion, the experimental group THP was diluted with 80 mL distilled water and the control group THP diluted with 40 mL distilled water. Results All cases were followed up for 2 years. There was no significant difference in relapse rate between the two groups (P> 0.05). The incidence of adverse reactions in the experimental group was significantly lower than that in the control group (P <0.05). Conclusion THP 40 mg + 80 mL distilled water instillation of bladder can significantly reduce the adverse reactions of bladder intravesical instillation of pirarubicin in patients with cancer, which is worth recommending.