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本文报道了TNT对大鼠毒作用所引起主要脏器的病理改变和某些生化指标的变化。对肝组织作了电镜观察。染毒早期可见肝内质网扩张。亚急性中毒肝线粒体变性和内质网扩张成小泡状。光镜检查见肝细胞浊肿、嗜酸变和嗜酸小体形成。生化指标测定中,LDH_1和LDH_2升高,提示TNT除作用于肝脏外,可能对心肌亦有作用。200mg/kg染毒一周,大鼠睾丸即出现明显的病理改变,因此,睾丸对TNT也是敏感的器官之一。
This article reports the toxic effects of TNT on the pathological changes of major organs and the changes of some biochemical indexes. Liver tissue was observed by electron microscopy. Early exposure to visible endoplasmic reticulum dilatation. Subacute poisoning of liver mitochondrial degeneration and endoplasmic reticulum dilated into vesicles. Light microscopy see hepatocyte turbid eosinophilic and eosinophilic formation. Determination of biochemical indicators, LDH_1 and LDH_2 increased, suggesting that in addition to acting on the liver, TNT may also have an effect on the myocardium. At a dose of 200 mg / kg for one week, the rat testis showed obvious pathological changes. Therefore, the testis is also one of the organs that are sensitive to TNT.