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目的探讨C-反应蛋白(CRP)与原发性高血压(EH)及其危险因素之间的关系。方法选择62例EH患者和69例健康的对照者,测定并比较其血清CRP水平[以高敏CRP(hs-CRP)衡量],并分析与其危险因素的关系。结果EH患者血清CRP水平与对照组之间的差异无统计学意义[(3.5±10.8)∶(2.3±13.1)mg/L],P>0.05。不同年龄、体质指数(BMI)组的血压及CRP水平的差异有统计学意义年龄≤49岁、50~59岁、≥60岁组,CRP水平分别为(0.16±1.20)、(0.00±1.08)、(0.82±1.19)mg/L,≥60岁组与另2组间差异有统计学意义(P<0.05);不同年龄组最高收缩压分别为(133±26)、(144±29)、(158±32)mmHg,≥60岁组与≤49岁组间差异有统计学意义(P<0.01)。BMI≤23、>23组,CRP水平分别为(-0.24±1.25)、(0.41±1.10)mg/L,差异有统计学意义(P<0.01);最高舒张压分别为(83±14)、(91±22)mmHg,差异有统计学意义(P<0.01)。结论EH与CRP之间并不一定直接相关,但年龄和BMI可能是其共同的影响因素。
Objective To investigate the relationship between C-reactive protein (CRP) and essential hypertension (EH) and its risk factors. Methods Sixty-two EH patients and 69 healthy controls were selected and their serum CRP levels were measured and compared [as measured by high-sensitivity CRP (hs-CRP)], and the relationship with risk factors was analyzed. Results The serum level of CRP in EH patients was not significantly different from that in the control group [(3.5 ± 10.8) :( 2.3 ± 13.1) mg / L], P> 0.05. There were significant differences in blood pressure and CRP level between different age and body mass index (BMI) groups. The levels of CRP in patients aged ≤49 years, 50 ~ 59 years and ≥60 years old were (0.16 ± 1.20) and (0.00 ± 1.08) , (0.82 ± 1.19) mg / L respectively. There was a significant difference between the groups of ≥60 and the other two groups (P <0.05). The highest systolic blood pressure in different age groups was (133 ± 26), (144 ± 29) (158 ± 32) mmHg, the difference between the groups of ≥60 years old and ≤49 years old was statistically significant (P <0.01). (P <0.01). The highest diastolic blood pressure was (83 ± 14), and the highest diastolic blood pressure was (-0.24 ± 1.25) and (0.41 ± 1.10) mg / (91 ± 22) mmHg, the difference was statistically significant (P <0.01). Conclusion There is not necessarily a direct correlation between EH and CRP, but age and BMI may be their common influential factors.