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为了探讨来自动态增强MRI(DCE-MRI)的灌注参数对于评估新辅助放化疗(CRT)治疗局部进展期直肠癌(LARC)的治疗反应的有效性,韩国仁济大学医学院云台Paik医院的Kim SH等人对50例行CRT和随后的外科手术的LARC患者(≥T3期或伴淋巴结转移)进行了研究,并利用后处理软件,以下列灌注参数(Ktrans、kep及ve?)对肿瘤进行测量。结果发现,行CRT后,T分期降期者的平均Ktrans明显降低(P=0.000 7),而未降期患者的平均Ktrans未见明显下降(P=0.24);T分期降期患者CRT
To investigate the effectiveness of perfusion parameters from dynamic contrast-enhanced MRI (DCE-MRI) in assessing response to neoadjuvant chemoradiation (CRT) therapy in the treatment of locally advanced colorectal cancer (LARC) Kim SH et al. Studied 50 patients with LARC (≥T3 stage or with lymph node metastases) undergoing CRT and subsequent surgery and using postprocessing software to evaluate the tumor response to the tumor with the following perfusion parameters (Ktrans, kep and ve?) Make measurements. The results showed that, after CRT, the mean Ktrans decreased significantly (P = 0.0007), while the average Ktrans in non-decreased patients had no significant decline (P = 0.24); T stage patients with CRT