论文部分内容阅读
目的:探讨骨桥蛋白(OPN)和细胞间黏附分子-1(ICAM-1)在非小细胞肺癌中的表达及其与临床病理特征的关系。方法:采用免疫组化S-P法检测40例非小细胞肺癌及40例癌旁组织中OPN及ICAM-1的表达。结果:OPN和ICAM-1在肺癌组织中高表达;二者表达与TNM分期及淋巴结转移有密切关系,与细胞分化程度无关;OPN表达在鳞癌中高于腺癌,ICAM-1在腺癌中表达高于鳞癌。结论:OPN和ICAM-1的表达与肺癌侵袭转移的发生有密切关系。
Objective: To investigate the expression of osteopontin (OPN) and intercellular adhesion molecule-1 (ICAM-1) in non-small cell lung cancer and its relationship with clinicopathological features. Methods: The expressions of OPN and ICAM-1 in 40 NSCLC tissues and 40 adjacent non-small cell lung cancer tissues were detected by immunohistochemical S-P method. Results: OPN and ICAM-1 were overexpressed in lung cancer tissues. The expressions of OPN and ICAM-1 were closely related to TNM stage and lymph node metastasis, but not to cell differentiation. OPN expression was higher in squamous cell carcinoma than in adenocarcinoma, and ICAM-1 was expressed in adenocarcinoma Higher than squamous cell carcinoma. Conclusion: The expression of OPN and ICAM-1 is closely related to the invasion and metastasis of lung cancer.