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目的观察经尿道膀胱肿瘤切除术(TUR-BT)后吡柔比星(THP)即刻膀胱灌注预防非肌层浸润性膀胱癌(NMIBC)复发的临床疗效。方法回顾性分析2000~2009年收治的301例非肌层浸润性膀胱癌行经尿道膀胱肿瘤切除术患者,随机分为治疗组(184例)和对照组(117例),治疗组术后24小时内行即刻膀胱灌注,对照组术后未行24小时内即刻膀胱灌注,随访比较两组患者的复发情况。结果患者术后24小时内行即刻膀胱灌注与肿瘤复发风险相关(HR=2.564,P<0.0001),但与肿瘤进展风险无关,治疗组和对照组无复发生存时间有显著的统计学差异(P<0.0001)。结论经尿道膀胱肿瘤切除术后24小时内行吡柔比星即刻膀胱灌注是预防非肌层浸润性膀胱癌复发有效的治疗方法。
Objective To observe the clinical efficacy of immediate intravesical instillation of pirarubicin (THP) to prevent the recurrence of non-muscle invasive bladder cancer (NMIBC) after transurethral bladder tumor resection (TUR-BT). Methods A retrospective analysis of 301 patients with non-muscle invasive bladder cancer who underwent transurethral resection of bladder tumor from 2000 to 2009 were randomly divided into treatment group (n = 184) and control group (n = 117) Conduct immediate bladder irrigation, the control group did not line within 24 hours immediately after bladder irrigation, follow-up comparison of two groups of patients relapse. Results Immediate intravesical instillation was associated with the risk of tumor recurrence within 24 hours after operation (HR = 2.564, P <0.0001), but not with the risk of tumor progression. The recurrence-free survival time was significantly different between the treatment group and the control group (P < 0.0001). Conclusion Immediate intravesical instillation of pirarubicin within 24 hours after transurethral resection of the bladder tumor is an effective treatment to prevent recurrence of non-muscular invasive bladder cancer.