论文部分内容阅读
目的探讨强直性脊柱炎(AS)主要的X线特点与发病年龄和人类白细胞抗原B_(27)(HLA-B_(27))的关系。方法回顾分析178例AS患者临床资料,比较不同X线分级各年龄患者比例及骶髂关节各X线分级HLA-B_(27)阳性率。结果 AS患者骶髂关节、髋关节、腰椎的相同X线分级中多以15~40岁患者所占比例最高,且骶髂关节、髋关节、腰椎的X线分级多以Ⅱ级最多;骶髂关节X线Ⅰ级(33.33%)、Ⅱ级(55.88%)、Ⅲ级(72.63%)、Ⅳ级(66.67%)阳性率比较,差异无统计学意义(P>0.05)。结论 AS患者骶髂关节破坏主要在年龄为15~40岁阶段,HLA-B_(27)阳性可作为早期诊断的重要指标。
Objective To investigate the relationship between major X-ray features and age of onset and HLA-B 27 (HLA-B 27) in ankylosing spondylitis (AS). Methods The clinical data of 178 AS patients were retrospectively analyzed. The proportions of patients with different grades of X-ray and the positive rates of HLA-B 27 in X-ray grading of sacroiliac joint were compared. Results Most of patients with AS in the same X-ray grading of sacroiliac joint, hip joint and lumbar spine had the highest proportion of patients aged 15 to 40 years, and most of the X-ray grading of sacroiliac joint, hip joint and lumbar spine were mostly in grade Ⅱ; sacroiliac There were no significant differences in the positive rates of grade Ⅰ (33.33%), grade Ⅱ (55.88%), grade Ⅲ (72.63%) and grade Ⅳ (66.67%) in joint X-ray. Conclusion The sacroiliac joint destruction in AS patients mainly occurs in the age of 15 to 40 years old, and HLA-B 27 positive can be used as an important index in early diagnosis.