目的探讨男性大型垂体泌乳素腺瘤的早期诊断与处理方法。方法回顾性分析本院收治的大型垂体泌乳素腺瘤3例，巨大型垂体泌乳素腺瘤1例，均为侵袭性生长。2例大型肿瘤仅给予多巴胺激动剂治疗。1例巨大型肿瘤6个月内行2次手术治疗，因肿瘤切除不完全，术后PRL水平>4000ug/L，也给以多巴胺激动剂(溴隐亭)治疗。结果2例大型肿瘤患者的PRL控制在正常水平，巨大型肿瘤患者的PRL水平<100ug/L。结论男性大型垂体泌乳素腺瘤的早期诊断需相关科室的密切合作。该肿瘤首选多巴胺激动剂治疗，药物治疗效果良好。术前PRL显著增高常预示手术效果不佳。“,”Objective To discuss early diagnosis and treatment for male macroprolactinomas.Methods 1 case was a imvasive giant prolactinoma,2 cases were invasive macroprolactinomas.2 patients with macroadenoma were only medical therapy with dopamine agonists (DA),the patient with giant prolactinoma was performed two operations,his tumor was removed uncompletely and PRL level was more than 4000Ug/L.He was also received mendical threapy with DA.Results The PRL level in two patients were normal.The PRL level in giant prolactinoma was less than 100 Ug/L. Conclusion The early diagnosis of male macroprolactinomas are demanded for relative doctors of cooperation.Medical therapy with DA is the first choice treatment of prolactinoma.The effect is well.A high preoperative level is predictive only factor of unsuccessful surgery.