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目的:评价依那普利治疗轻、中度原发性高血压对一氧化氮(NO)、内皮血管性血友病因子(vWF)的影响。方法:选取轻、中度原发性高血压患者45例及正常对照组30例,原发性高血压组服用依那普利20mg/d,分别对治疗前、治疗16周后及正常对照组行血浆NO、vWF检测。结果:治疗前血浆NO较正常对照组降低(P<0.05),治疗后血浆NO较治疗前明显升高(P<0.01)。治疗前血浆vWF较正常对照组明显升高(P<0.01),治疗后血浆vWF较治疗前降低(P<0.05)。结论:依那普利明显升高血浆NO、降低vWF,说明它在降压的同时具有保护血管内皮细胞的功能。
Objective: To evaluate the effects of enalapril treatment on nitric oxide (NO) and von Willebrand factor (vWF) in mild to moderate essential hypertension. Methods: Forty-five patients with mild to moderate essential hypertension and 30 normal controls were enrolled. Essential hypertension patients were enalapril 20mg / d, respectively, before and 16 weeks after treatment and normal control group Plasma NO, vWF test. Results: Before treatment, NO in plasma was lower than that in normal control group (P <0.05). After treatment, plasma NO was significantly increased (P <0.01). The vWF in plasma before treatment was significantly higher than that in the normal control group (P <0.01). After treatment, the plasma vWF was lower than before treatment (P <0.05). Conclusion: Enalapril significantly increased plasma NO and decreased vWF, indicating that it has the function of protecting vascular endothelial cells while lowering blood pressure.