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目的 探索肠道线虫病不同流行区的集体化疗方案 ,为指导防治工作提供决策依据。方法 选择江苏省不同状况的 3个村 ,分别采用每年 1次或 2次集体化疗并连续 3年 ;对人群肠道线虫感染和土壤中虫卵、钩虫幼虫污染情况进行观察研究。结果 苏南试点村连续 3年每年 1次集体化疗后 ,肠道线虫总感染率从 32 .33%降至 2 .0 8% ;钩、蛔、鞭虫的单虫感染率比防治前分别下降94 .4 7%、 86 .6 0 %、92 .6 2 %。苏中和苏北试点村经过 3年 6次集体化疗 ,总感染率由防治前的86 .80 %和 88.76 %下降至 5 .11%和 7.98% ;单虫感染率均比化疗前下降 90 %以上 ,苏北试点村钩虫感染率降至 0。感染度、多重感染和土壤中虫卵、钩虫幼虫污染情况与感染率同步下降。结论 在肠道线虫病不同流行区应采用不同的集体化疗方案 ,以保证防治效果 ,避免盲目用药 ;对感染率30 %左右的地区 ,每年 1次集体化疗连续 2 - 3年即可降至 5 %以下 ,在感染率高达 80 %以上的地区 ,每年 2次 ,连续 2 - 3年亦可将感染率降至 10 %以下。
Objective To explore the collective chemotherapy regimens in different endemic areas of gut nematode disease and provide decision-making basis for guiding prevention and control work. Methods Three villages with different status in Jiangsu Province were selected for one year or two times of collective chemotherapy for three consecutive years respectively. Intestinal nematode infection and contamination of eggs and hookworm larvae in the soil were observed. Results The total infection rate of intestinal nematodes decreased from 32.33% to 2.08% after one year of collective chemotherapy in the experimental villages in southern Jiangsu Province for three consecutive years. The infection rates of monostras of hook, roundworm and whipworm were decreased 94.4%, 86.60%, 92.62%. After three years of 6 collective chemotherapies in the pilot villages of Central Jiangsu and Jiangsu provinces, the total infection rate decreased from 86.80% and 88.76% to 5.111% and 7.98% before prevention and treatment. The infection rates of single insects decreased by 90% Above, the hookworm infection rate in pilot villages in northern Jiangsu Province dropped to zero. Infection, multiple infections and soil eggs, hookworm larvae contamination and infection rate decreased simultaneously. Conclusion In different prevalence areas of gut nematode, different chemotherapy should be adopted in order to ensure the prevention and treatment effect and avoid blind medication. For the area with infection rate of 30%, once a year, the collective chemotherapy can be reduced to 5 for 2-3 consecutive years %, The rate of infection can be reduced to less than 10% for 2 to 3 consecutive years in areas with an infection rate as high as 80% or more.