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目的五味清胆方联合西药治疗Hp相关的慢性非萎缩性胃炎隆起糜烂(HpVG)湿热证患者临床疗效。方法135例入选患者随机分为3组:联合用药组,即西药三联疗法治疗10日清除Hp后,序贯服用中药联合PPI制剂80日,共达12周疗程;中药组,服中药治疗10日清除Hp后,序贯服用80日,共达12周疗程;西药组,三联疗法治疗10日清除Hp后,序贯服用PPI制剂80日,共达12周疗程。治疗10天、疗程结束后4周分别进行Hp检测,治疗前后的临床疗效分析及序贯治疗前后胃肠道不良反应比较。结果治疗后临床疗效比较,联合组优于中药组,中药组优于西药组(P﹤0.05);三组治疗10天后对Hp清除比较,联合用药组疗效优于其余两组(P<0.05);中药组与西药组无差别(P>0.05);疗程结束后4周对Hp的清除比较,联合用药组疗效优于其余两组(P<0.05);中药组疗效优于西药组(P<0.05);三组序贯治疗前后胃肠道不良症候积分比较,序贯治疗后各组患者不良反应均少于治疗前(P<0.05);且联合用药组明显少于中药组、西药组(P<0.01),中药组明显少于西药组(P<0.01)。结论五味清胆方治疗HpVG湿热证患者,能改善患者的临床症候,对Hp有良好的清除疗效,并能维持其清除疗效,降低复发率,其联合西药三联疗法对清除Hp后的预防复发具有减毒增效效应,且能减少西药胃肠道的不良反应。
Objective To observe the clinical effect of combined treatment of Wuwei Qingqi Recipe and western medicine on Hp-related chronic non-atrophic gastritis patients with hypopyon-induced erosion (HpVG) damp-heat syndrome. Methods One hundred and thirty-five selected patients were randomly divided into three groups: the combination group, that is, western medicine triple therapy to eliminate Hp on the 10th, followed by sequential combination of traditional Chinese medicine and PPI formulation for 80 days for 12 weeks; Chinese medicine group, After clearing Hp, taking 80 days sequentially, a total of 12 weeks course of treatment; western medicine group, triple therapy for 10 days to clear Hp, PPI preparation for 80 days, a total of 12 weeks course of treatment. Treatment for 10 days, 4 weeks after the end of treatment for Hp detection, clinical efficacy before and after treatment and sequential treatment of gastrointestinal adverse reactions before and after comparison. Results Compared with the traditional Chinese medicine group, the combination group was superior to the traditional Chinese medicine group (P <0.05). After the treatment for 10 days, the curative effect of Hp group was better than that of the other two groups (P <0.05) (P <0.05). Compared with the other two groups (P <0.05), the curative effect of combination group was better than western medicine group (P < 0.05). The scores of gastrointestinal adverse symptom scores before and after sequential treatment in three groups were significantly lower than those before treatment (P <0.05), and the adverse reactions in all groups after sequential treatment were less than those before treatment (P <0.05) P <0.01), Chinese medicine group was significantly less than western medicine group (P <0.01). Conclusions Wuwei Qing Gou Decoction can treat patients with HpVG damp-heat syndrome, improve the clinical symptoms, relieve Hp and maintain its clearance efficacy and reduce the recurrence rate. Combined with western medicine triple therapy, it has the following effects Attenuated synergistic effect, and can reduce the gastrointestinal side effects of western medicine.