胰淀素是胰岛β细胞分泌的一种37个氨基酸的多肽,在体内有糖基化和非糖基化胰淀素两种存在形式。胰淀素可调节胰岛素分泌,降低胰岛素敏感性。研究表明,胰淀素可能通过升高游离脂肪酸,改变磷蛋白的磷酸化位点,以及降低胰岛素受体激酶活性等多种途径诱导胰岛素抵抗的发生。 Amylin is a 37 amino acid polypeptide secreted by pancreatic β cells, both in the form of both glycosylated and non-glycosylated amylin. Amylin can regulate insulin secretion, reduce insulin sensitivity. Studies have shown that amylin may induce insulin resistance by increasing free fatty acids, changing the phosphorylation sites of phosphoproteins, and decreasing insulin receptor kinase activity.