The Call of the Wild, one of the most popular novels in the early twentieth-century America, is the first best-selling book of Jack London. As far as this novel is concerned, the main character Buck represents nature. He deals with all kinds of peo?ple. The good treat Buck (nature) very well and live harmoniously with him. The evil treat Buck (nature) maliciously, just like fight?ing against their enemies. This novel shows the damages people did to nature and the imbalance between human being and nature. The author”s ecological awareness finds its full expression in the novel. The relationship between human and nature in the novel will be analyzed from the perspective of eco-criticism and the ecological theme of the novel will be discussed in a bid to arouse peo?ple”s ecological consciousness and environmental protection awareness.