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目的研究依扑拉芬的抗炎镇痛作用。方法用二甲苯及角叉菜胶分别诱导小鼠耳肿胀及大鼠踝关节肿胀模型，用冰醋酸、热及电刺激分别制备小鼠扭体、热板及电嘶叫疼痛模型。结果依扑拉芬（ｉｇ，５０，１００，２００ｍｇｋｇ－１）对二甲苯诱导的小鼠耳肿胀度有明显抑制作用，也可剂量依赖性地抑制小鼠扭体反应，显著延长小鼠热板的舔足反应潜伏期及提高小鼠的电嘶叫刺激阈值，但对角叉菜胶诱导的大鼠踝关节肿胀度没有明显影响。结论依扑拉芬具有明显抗炎镇痛作用
Objective To study the anti-inflammatory and analgesic effects of torafen. Methods Xylene and carrageenan were used to induce ear edema in mice and ankle swelling in rats. The mice models of writhing, hot plate and electric sizzle were prepared by acetic acid, heat and electric stimulation respectively. Results Toxoparafen (ig, 50, 100, 200 mg kg-1) significantly inhibited xylene-induced ear swelling in mice and also inhibited the writhing response in mice in a dose-dependent manner, significantly prolonging the mouse hot plate Of licking foot reaction latency and raising the threshold of electrosurgical stimulation in mice, but had no significant effect on carrageenan-induced ankle swelling in rats. Conclusion Tacrolimus has obvious anti-inflammatory and analgesic effects