本文报告了在40～50%的炎症性肠病(IBD)患者中分离出细菌L型(以下简称L型)。从而进一步证实IBD和细菌L型之间有着密切的联系。L型是普通细菌的细胞壁缺陷型变种,它仍能持续生长、分裂和产生毒素,并能回复到亲代细菌。其存活需要一个高渗环境,以满足渗透压和代谢方面的需要。作者对44例克隆氏病、69例溃疡性结肠炎和75例非炎症性肠病的对照组,在纤维结肠镜下进行了肠粘膜组织活检;并将这些活检标本的组织匀浆在特制的高渗培养基中进行培养。L型培养的阳性率在克隆氏病(CD)组是45.4%、溃结(UC)组是 This paper reports the isolation of bacterial L-form (hereinafter referred to as L-form) in 40-50% of patients with inflammatory bowel disease (IBD). This further confirms the close relationship between IBD and bacterial L-type. The L-type is a cell-wall deficient variant of common bacteria that continues to grow, divide, and produce toxins and reverts to the parent bacteria. Its survival requires a hypertonic environment to meet the needs of osmotic pressure and metabolism. The authors performed colon biopsies of 44 patients with Crohn’s disease, 69 with ulcerative colitis and 75 with noninflammatory bowel disease. Colon biopsies of these biopsies were made in specially prepared Culture in hypertonic medium. The positive rate of L-type culture was 45.4% in the Crohn’s disease group (CD) and in the UC group