膀胱输尿管反流Ⅰ～Ⅲ度常行保守治疗,Ⅳ～Ⅴ度则行手术,Schulman等曾用内腔镜向有反流的输尿管口的粘膜下注射聚四氟乙烯(teflon)治疗Ⅰ～Ⅴ度反流的病人,治愈率为85%,有些作者用灵长类动物做试验,发现teflon颗粒可迁移到淋巴结、肺和脑内,且可能有致癌作用,因而反对这种方法,但该法简单易行,疗效高,作者乃用牛胶原代替teflon行输尿管口粘膜下注射,治疗了45例70侧有反流的输尿管,60侧治愈,治愈率为85.8%。 45例中4例为Ⅳ度反流,其余病例为Ⅰ～Ⅲ度,所有病人都有泌尿系感染,需长期或间断用抗菌药物治疗,70侧中18侧输尿管注射了第二次,随访半年到2年,60侧已无反流,13例还有泌尿系感染,5例无效,做了手术治疗,切除注射有牛胶原的组织,做病理切片,未发现炎症 Bladder ureter reflux Ⅰ ~ Ⅲ degree conservative treatment often, Ⅳ ~ Ⅴ degree surgery, Schulman et al had endoscopic endoscopic retrograde ureteral orifice submucosal injection of teflon (Ⅰ ~ Ⅴ degree Reflux of patients, the cure rate was 85%, some authors used primate experiments, found that teflon particles can migrate to the lymph nodes, lungs and brain, and may have carcinogenic, and thus against this method, but the method is simple Easy to operate and high curative effect. The authors used subcutaneous injection of bovine collagen instead of teflon to treat 45 cases of ureter with reflux on the 70 side, and 60 cases cured. The cure rate was 85.8%. Four of the 45 patients had grade IV reflux and the remaining cases were grade I to III. All patients had urinary tract infections requiring long-term or intermittent antimicrobial treatment and 18 of the 70 sides were injected with the second ureter for a median of six months By 2 years, 60 patients had no reflux, 13 patients had urinary tract infections, and 5 patients were ineffective. Surgical treatment was performed. The tissues injected with bovine collagen were excised and pathological sections were performed. No inflammation was found