基本性质及药效学:拉贝洛尔(labetalol)为一具非选择性竞争性β受体拮抗作用及选择性突触后α_1阻滞作用的抗高血压药,β与α阻滞活性之比约7∶1。临床上它具有心得安β阻滞活性的1/4、酚妥拉明α阻滞活性的1/2。与单纯α或β受体阻滞药(如酚妥拉明或心得安)相比,拉贝洛尔有许多优点:降压作用强,起效快,能稳定地控制血压24小时,体位性低血压副作用小,特别是对正常血液动力学影响小,能降低外周阻力、减 Basic Properties and Pharmacodynamics: Labetalol is an antihypertensive drug with a nonselective competitive beta-receptor antagonism and selective post-synaptic alpha-1 blockade, beta and alpha blockade About 7: 1. It has clinically patented β-arrestive activity of 1/4, phentolamine α-blocking activity of 1/2. Labelolol has many advantages over pure alpha or beta blockers (such as phentolamine or propranolol): strong antihypertensive action, rapid onset of action, stable blood pressure control for 24 hours, Low side effects of hypotension, in particular, have little effect on normal hemodynamics, can reduce peripheral resistance, reduced