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摘要目的探讨动态增强MRI(DCE-MRI)能否区分N-亚硝基二乙胺诱导大鼠模型肝硬化结节的类型。方法通过饮用含有0.01%N-亚硝基二乙胺的饮用水35~100 d诱导60只雄性Wistar大鼠形成肝硬化结节。结节分为3组:再生结节(RN)、发育不良结节(DN)和肝细胞癌(HCC)。进行DCEMRI检查,参数包括容量转移常数(K~(trans))、速率常数(k_(ep))、血
Abstract Objective To investigate whether dynamic enhanced MRI (DCE-MRI) can differentiate the types of cirrhotic nodules induced by N-nitrosodiazepine in rats. Methods Sixty male Wistar rats were induced to develop cirrhosis nodules by drinking drinking water containing 0.01% N-nitrosodiethylamine for 35 to 100 days. Nodules are divided into three groups: regenerative nodules (RN), dysplastic nodules (DN) and hepatocellular carcinoma (HCC). The DCEMRI test was performed and the parameters included the capacity transfer constant (K ~ (trans)), rate constant (k ep), blood