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对乳鼠与10月龄成年大鼠的晶状体代谢进行比较。结果表明,年成大鼠晶状体脂类过氧化作用较乳鼠显著高(P<0.05),而非蛋白质就基含量则较乳鼠低约22％(P<0.01),谷胱甘肽过氧化物酶(GSH-Px)活性随鼠龄增长而逐渐下降,成年大鼠GSH-Px活性较18日龄乳鼠降低62％(P<0.01),成年大鼠的谷胱甘肽还原酶活性较18日龄乳鼠低47％(P<0.01),而谷胱甘肽硫转移酶则高14％(P<0.01)。据此结果推测,去年性白内障的发生可能与晶状体抗氧化遗伤的防御机制减弱与脂类过氧化作用增加有关。而乳鼠晶状体谷胱甘肽硫转移酶(GST)活性低于成年大鼠或许是某些中毒性白内障只可在幼年动物诱发成功的影响因素之一。
The lens metabolism in suckling mice and 10-month-old adult rats was compared. The results showed that lipid peroxidation in lens of adult rats was significantly higher than that of the control rats (P <0.05), but non-protein content was about 22% lower than that of the control rats (P <0.01). Glutathione peroxidation The activity of GSH-Px decreased gradually with the growth of mice, and the activity of GSH-Px in adult rats decreased by 62% (P <0.01) compared with that of 18-day-old rats. The activity of glutathione reductase 18-day-old suckling rats were 47% lower (P <0.01), while glutathione S-transferase was 14% (P <0.01) higher. According to the results speculated that the incidence of cataracts last year may be associated with lens antioxidant defense injury mechanism of weakening and increased lipid peroxidation. However, the activity of glutathione S-transferase (GST) in neonatal rat lens is lower than that in adult rats and may be one of the influencing factors for the success of some toxic cataract induced in juvenile animals.