频繁的化疗和放疗可促进肿瘤细胞的自我吞噬,即细胞内一种溶酶体相关的降解途径。然而,这种途径是否使肿瘤细胞对治疗耐受,或是否代表细胞死亡的一个非凋亡形式,还存在争议。Amaravadi等的研究表明,除化疗外,阻断自体吞噬作用也可导致癌细胞加速死亡。这为进一步探讨自体吞噬抑 Frequent chemotherapy and radiotherapy can promote tumor cell self-phagocytosis, a lysosomal-related degradation pathway in cells. However, whether this pathway renders tumor cells resistant to treatment or whether it represents a non-apoptotic form of cell death remains controversial. Amaravadi et al.’s study showed that in addition to chemotherapy, blocking autophagy can also lead to accelerated death of cancer cells. This is to further explore autophagy inhibition