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目的:探讨钙剂联合骨化三醇治疗绝经后妇女骨质疏松的临床疗效。方法:回顾性分析2009年5月至2011年4月广东省揭阳市妇幼保健院收治的68例绝经后妇女骨质疏松患者的临床资料。对照组(34例)服用钙尔奇D,观察组(34例)服用钙尔奇D+骨化三醇,共6~12个月。监测治疗前后骨密度(BMD)、骨钙素(BGP)、血清IL-6、TNF-a变化情况。结果:对照组腰椎侧位(L2-4)BMD、血清BGP、IL-6、TNF-a治疗前后差异无统计学意义(P>0.05);治疗后,观察组腰椎侧位(L2-4)BMD、血清BGP较治疗前明显增加(P<0.01)。观察组治疗后血清IL-6、TNF-a浓度均较治疗前降低(P<0.05)。结论:钙剂联合骨化三醇治疗绝经后妇女骨质疏松疗效肯定,可提高骨BMD、BGD,降低血清IL-6、TNF-a浓度。
Objective: To investigate the clinical efficacy of calcium combined with calcitriol in the treatment of postmenopausal women with osteoporosis. Methods: The clinical data of 68 postmenopausal women with osteoporosis admitted to Jieyang Maternal and Child Health Hospital of Guangdong Province from May 2009 to April 2011 were retrospectively analyzed. The control group (34 cases) took Calcium D, while the observation group (34 cases) took Calcium D + calcitriol for 6 to 12 months. The changes of BMD, BGP, IL-6 and TNF-a before and after treatment were monitored. Results: There was no significant difference in BMD of L2-4, serum BGP, IL-6 and TNF-α before and after treatment in control group (P> 0.05). After treatment, the lumbar lateral position (L2-4) BMD and serum BGP were significantly increased (P <0.01). The levels of serum IL-6 and TNF-a in observation group were lower than those before treatment (P <0.05). Conclusion: Calcium combined with calcitriol in the treatment of postmenopausal women osteoporosis positive effect, can increase bone BMD, BGD, reduce serum IL-6, TNF-a concentration.