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依常法建立以黄曲霉素Ｂ１（ＡＦＢ１）诱发ＳＤ和Ｗｉｓｔａｒ大鼠肝癌癌前病变实验动物模型，实验组分别给予０．５％、１％、２％的绞股蓝总皂甙（第２程序，即第１法），２％，４％，８％的绞股蓝总皂甙（第２程序，即第２法）药化性饲料，空白对照组及阳性对照组饲标准基础饲料。通过肝组织γ－ＧＴ阳性灶定量计数。结果表明，绞股蓝总皂甙（按上述６种浓度给药），对ＡＦＢ１的致肝癌作用无抑制作用，高浓度（４％、８％）似乎提示有轻度促进作用。
The animal model of precancerous lesions of SD and Wistar rats induced by AFB1 was established according to the common method. The experimental group was given 0.5%, 1%, and 2% total saponins of Gynostemma pentaphyllum (Step 2). That is, the first method), 2%, 4%, 8% of the total saponins of Gynostemma pentaphyllum (the second procedure, ie, the second method) of medicinal feed, blank control group and positive control group feeding standard basal feed. Quantitative counts were made by liver tissue gamma-GT positive foci. The results showed that Gynostemma saponins (administered in the above six concentrations) had no inhibitory effect on the liver cancer effect of AFB1, and high concentrations (4%, 8%) appeared to suggest a mild promotion effect.